Key Scientific Studies in AstraZeneca’s Asthma Research

As part of AstraZeneca’s commitment to provide healthcare professionals and patients with meaningful information to aid in making the best decision about treatment, details about all AstraZeneca asthma clinical trials are provided on AstraZenecaClinicalTrials.com.

The following six asthma trials (STEP, STEAM, SMILE, STAY, COMPASS and AHEAD) represent some of the key clinical data supporting the Symbicort SMART® indication and a summary for each asthma study is provided.

• STEP study  [ClinicalTrials.gov Identifier SD 039 0668] Scicchitano R, Aalbers R, Ukena D, et al Efficacy and safety of budesonide/formoterol single inhaler therapy versus a higher dose of budesonide in moderate to severe asthma. Curr Med Res Opin 2004; 20:1403–1418.
• STEAM study  [ClinicalTrials.gov Identifier: SD-039-0667] Rabe KF, Pizzichini E, Stallberg B, et al. Budesonide/formoterol in a single inhaler for maintenance and relief in mild-to-moderate asthma: a randomised, double-blind trial. Chest 2006;129(2): 246-56.
• STAY study  [ClinicalTrials.gov Identifier: SD-039-0735] O'Byrne PM, Bisgaard H, Godard PP, et al. Budesonide/formoterol combination therapy as both maintenance and reliever medication in asthma. Am J Respir Crit Care Med 2005;171(2): 129-36.
• SMILE study  [ClinicalTrials.gov Identifier: SD-039-0734] Rabe KF, Atienza T, Magyar P, et al. Effect of budesonide in combination with formoterol for reliever therapy in asthma exacerbations: a randomised controlled, double-blind study. Lancet 2006; 368:744–753.
• COMPASS study  [ClinicalTrials.gov Identifier SD-039-0735] Kuna P, Peters MJ, Manjra AI, et al. Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations. Int J Clin Pract 2007; 61:725–736.
• AHEAD study  [ClinicalTrials.gov Identifier NCT00242775] Bousquet J, Boulet LP, Peters MJ, et al. Budesonide/formoterol for maintenance and relief in uncontrolled asthma versus high-dose salmeterol/fluticasone. Respir Med 2007; 101:2437–2446.